SAIZEN stimulates growth of bones, cells, and organs. Clinical studies have shown that it causes a decrease in body fat and an increase in bone growth and muscle mass.

The Bacteriostatic water that comes with SAIZEN contains the preservative benzyl alcohol, which should not be used in newborns or patients with a known sensitivity to benzyl alcohol. For these patients, SAIZEN may be reconstituted with Sterile Water for Injection, USP. When it is reconstituted in this manner, it must be used immediately and any unused portion must be discarded. Growth Hormone may trigger insulin resistance and should be used with caution in patients who have diabetes mellitus or a family history of diabetes mellitus. Inform your doctor of any diabetes in the patient's family. SAIZEN should not be used in patients who have active cancerous or benign tumors. Patients with a history of cancer should be monitored closely.

In clinical studies in which SAIZEN was given to children with Growth Hormone deficiency, the following reactions were infrequently seen: pain, numbness, redness, or swelling at the delivery site, hypothyroidism (low thyroid hormone), hypoglycemia (low blood sugar), seizures or convulsions, water retention, and worsening of psoriasis symptoms that existed before therapy began. 

Any patient who has a Growth Hormone deficiency and does not respond to therapy should be tested for thyroid problems or antibodies to Human Growth Hormone. Either of these conditions can reduce the effectiveness of SAIZEN.