Abilify is prescribed for:
- Major depressive disorder (adjunct treatment)
- Schizophrenia in adults/adolescents
- Bipolar disorder (manic/mixed episodes)
- Irritability associated with autism in pediatric patients
Mechanism of Action
- Partial agonist at D2 and 5-HT1A receptors
- Antagonist at 5-HT2A receptors
- Moderate affinity for histamine/alpha-adrenergic receptors
Dosage & Administration
- Initial dose: 10-15mg once daily
- May be adjusted based on response
- Can be taken with/without food
Important Safety Information
Contraindications:
- Hypersensitivity to aripiprazole
- Breastfeeding
Precautions:
- Increased suicide risk in young patients
- Not for dementia-related psychosis in elderly
- May impair judgment/motor skills
- Risk of hyperglycemia (monitor blood sugar)
- Avoid alcohol and overheating
Potential Side Effects
Common:
- Nausea/constipation
- Headache/dizziness
- Insomnia/restlessness
- Weight gain
Serious (seek medical help):
- Neuroleptic malignant syndrome
- Tardive dyskinesia
- Stroke risk
- Uncontrolled movements
Drug Interactions
Levels decreased by:
- Carbamazepine
- Phenytoin
- Rifampin
Levels increased by:
- Ketoconazole/other antifungals
- Fluoxetine/paroxetine
- Quinidine
Missed Dose/Overdose
- Missed dose: Take when remembered (skip if near next dose)
- Overdose symptoms: Vomiting, tremors, cardiac abnormalities
Storage Instructions
- Keep at room temperature
- Store in original container
- Protect from moisture
Note: Regular monitoring required for glucose levels and neurological symptoms. Report any unusual movements or mood changes to your doctor immediately.